制服驢妖馬盧後，捉妖師宋定伯（陳浩民）名聲大噪。不料馬盧逃跑，宋定伯尾隨發現村民欲將少女蕭蕭獻祭，陰差陽錯救下他並打敗蛇妖。原來蕭蕭的真實身份為當今三公主，懷疑在朝中妖言惑眾的國師是妖，希望宋定伯一同入京協助除妖。豈料，國師不僅用天機儀害人，更變幻成蛟龍與宋定伯大戰…
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